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Enzo Life Sciences Gliotoxin (2mg). CAS: 67-99-2
Supplier: Enzo Life Sciences BMLPI1290002
Immunomodulating mycotoxin which acts by blocking membrane thiol groups. Inhibits the chymotrypsin-like activity of the 20S proteasome in a non-competitive manner. Causes apoptotic cell death in macrophages and thymocytes. Induces Ca2+ release from intact rat liver mitochondria. Inhibits the activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells. Displays anti-inflammatory activity in vivo. Antioxidant. Inhibitor of farnesyltransferase and geranylgeranyltransferase I. A negative control analog is available (BML-L122). Displays anti-tumor activity against breast cancer in vivo. Alternative name: [3R-(3alpha, 5abeta,6beta,10aalpha)]-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epi-dithiopyrazino[1,2-a]indole-1,4-dione. Purity: ≥97% (HPLC, TLC). Solubility: Soluble in DMSO or methanol (10mg/ml). Long Term Storage: -20°C.
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