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Medchemexpress LLC Glucosylsphingosine | 52050-17-6 | 1 MG
Supplier: Medchemexpress LLC HYN7745S1MG
Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide exhibiting neurotoxicity. It acts as a noncompetitive inhibitor of glucocerebrosidase with a Ki value of 30 μM. This compound is promising for research into Krabbe and Gaucher diseases.
- Acts as a noncompetitive inhibitor of glucocerebrosidase.
- Promising for research of Krabbe and Gaucher disease.
- Induces LA-N-2 cell shriveling and suppresses neurite outgrowth in vitro.
- Reduces activities of lysosomal enzymes including glucocerebrosidase, sphingomyelinase, and β-galactosidase.
- Causes cell death in MCF7 cells independently of apoptosis, ferroptosis, and necroptosis.
- Activates the cAMP signaling pathway.
- Induces a visceral inflammatory response in mice.
- Accumulates in peripheral tissues and causes hematological symptoms in mice.
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