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Cayman Chemical GluCys ammonium salt 50mg
SDP

Supplier:  Cayman Chemical 3056950 MG

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An inhibitor of Cdk8 and Cdk19 inhibits Cdk8 (IC50s 24-50 nM depending on assay) selectively inhibits Cdk19 and Cdk8 by 98 6 and 97 8 respectively in a panel of 450 kinases at 2 M but does inhibit MAP4K2 and YSK4 by 69 and 59 respectively inhibits cell growth in MCF-7 BT474 and T47D-ER/Luc breast cancer cells in estrogen-containing media at 1 25-5 M reduces tumor growth in an MCF-7 mouse xenograft model at 100 mg/kg twice per day inhibits RANKL-induced differentiation of murine BMDMs into osteoclasts at 1 and 1 5 M increases the bone volume fraction and bone mineral density in injured tibiae in a rat model of cancellous bone injury and regeneration when administered locally at 1 g

Catalog No. 50-299-2184


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