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Apexbio Technology LLC GNE-317 1394076-92-6 100mg
Supplier: Apexbio Technology LLC B4991100
GNE-317 (CAS 1394076-92-6) is a potent small-molecule inhibitor targeting phosphatidylinositol 3-kinase (PI3K) a family of enzymes crucially involved in cellular proliferation survival differentiation migration and intracellular trafficking processes In experimental studies using GL261 U87 GS2 and GBM10 glioblastoma tumor models GNE-317 effectively crosses the blood-brain barrier resulting in significant reductions of phosphorylated Akt 4EBP1 and S6 kinase downstream biomarkers indicative of PI3K/mTOR pathway inhibition Consequently GNE-317 serves as a valuable research tool for studying PI3K-mediated signaling in brain tumor models
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