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Medchemexpress LLC GNE-477 | 1032754-81-6 | 98.8% | 504.63 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1104250MG

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GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor. It is intended for research use only. In vitro, GNE-477 (Compound 8) shows improved potency in the MCF7.1 cell proliferation assay with an EC50 of 143 nM. In vivo, GNE-477 exhibits tumor growth stasis in a PC3 tumor growth inhibition study.

  • Potent and efficacious dual PI3K/mTOR inhibitor
  • Improved potency in cell proliferation assays
  • Exhibits tumor growth stasis in studies
  • Generally well tolerated

Catalog No. 50-003-43635


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