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Apexbio Technology LLC GNE-617 hydrochloride 10mg
Supplier: Apexbio Technology LLC B130910
GNE-617 hydrochloride is a small-molecule inhibitor targeting nicotinamide phosphoribosyltransferase (NAMPT) It is designed to inhibit NAMPT thereby disrupting NAD biosynthesis in cells GNE-617 hydrochloride exerts its biological activity primarily by competitively inhibiting the NAMPT substrate leading to decreased intracellular NAD levels In cell-based studies GNE-617 hydrochloride demonstrates nanomolar-range antiproliferative activity in multiple cancer cell lines including glioblastoma (U251) fibrosarcoma (HT1080) prostate carcinoma (PC3) pancreatic adenocarcinoma (MiaPaCa2) and colon carcinoma (HCT116) Based on these pharmacological properties GNE-617 hydrochloride holds research potential in the investigation of NAMPT-dependent cancer biology and therapeutic applications
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