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Selleck Chemical LLC GNE-781
Supplier: Selleck Chemical LLC S8665100MG
GNE-781 (compound 19) is an orally active highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0 94 nM in TR-FRET assay GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6 2 nM and 5100 nM respectively GNE-781 exhibits antitumor activity
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