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Apexbio Technology LLC GNE-9605 1536200-31-3 5mg
Supplier: Apexbio Technology LLC B47615
GNE-9605 (CAS 1536200-31-3) is a selective brain-penetrant inhibitor of leucine-rich repeat kinase 2 (LRRK2) a kinase implicated in the pathogenesis of Parkinson s disease and Crohn s disease GNE-9605 exhibits high potency against LRRK2 with a reported Ki of 2 0 nM and IC50 of 18 7 19 nM In pharmacokinetic studies GNE-9605 demonstrates excellent metabolic stability in human hepatocytes and high oral bioavailability (90%) in rats In BAC transgenic mice expressing the G2019S LRRK2 mutation GNE-9605 potently inhibits LRRK2 Ser1292 autophosphorylation in a dose-dependent manner This compound supports preclinical investigations of LRRK2 signaling and its role in neurodegenerative disease
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