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Medchemexpress LLC GNE-9815 | 2729996-45-4 | 98.9% | C26H22FN5O2 | 1 ML
Supplier: Medchemexpress LLC HY14216010MM/1ML
GNE-9815 is a highly selective, pan-RAF inhibitor exhibiting good oral bioavailability. It demonstrates potent inhibition of CRAF (Ki 0.062 nM) and BRAF (Ki 0.19 nM). When combined with the MEK inhibitor Cobimetinib, GNE-9815 shows synergistic modulation of the MAPK pathway, making it suitable for studies in KRAS mutant cancers.
- Highly selective pan-RAF inhibitor
- Good oral bioavailability
- Potent inhibition of CRAF and BRAF
- Synergistic with Cobimetinib in MAPK pathway modulation
- Useful in KRAS mutant cancer research
- Demonstrates synergistic antiproliferative activity against human A549 and HCT116 cancer cells
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