Apexbio Technology LLC GNF 2 778270-11-4 25mg

Supplier:  Apexbio Technology LLC A860325

GNF 2 (CAS 778270-11-4) is a small-molecule inhibitor targeting Bcr-Abl kinase It is designed to suppress Bcr-Abl-mediated signaling thereby regulating leukemic cell proliferation GNF 2 exerts its biological activity primarily through non-ATP competitive allosteric inhibition at the myristate-binding pocket of Abl In cell-based studies GNF 2 demonstrates inhibitory activity with an IC50 of approximately 138 nM in Ba/F3 p210 cells expressing wild-type Bcr-Abl It also inhibits mutant Bcr-Abl forms (E255V Y253H) and proliferation of K562 and SUP-B15 human leukemia cell lines with IC50 values of 194 273 nM Based on these pharmacological properties GNF 2 holds research potential in chronic myeloid leukemia (CML) pathogenesis and therapeutic response studies involving Bcr-Abl fusion proteins

Catalog No. 50-000-95179