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Apexbio Technology LLC GNF-7 839706-07-9 25mg
Supplier: Apexbio Technology LLC B603325
GNF-7 (CAS 839706-07-9) is a small molecule type II kinase inhibitor that selectively targets the T315I mutant form of Bcr-Abl a constitutively active tyrosine kinase implicated in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia In vitro GNF-7 exhibits potent growth inhibitory effects in Colo205 SW620 and TrkC-Ba/F3 cell lines with IC50 values of 0 005 0 001 and 0 008 M respectively while displaying minimal activity on normal HEK293T cells In vivo GNF-7 reduces disease burden and improves survival in mouse leukemia models and selectively suppresses NRAS-dependent leukemia cells GNF-7 is valuable for research into kinase inhibitor resistance and targeted leukemia therapies
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