Medchemexpress LLC GNF4877 | 2041073-22-5 | 99.8% | 10 MG

Supplier:  Medchemexpress LLC HY12949210MG

GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively. It leads to the blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). It is for research use only and not sold to patients.

• Potent DYRK1A inhibitor (IC50 of 6 nM)
• Potent GSK3β inhibitor (IC50 of 16 nM)
• Leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export
• Increases β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells)
• Induces β-cell proliferation, increases β-cell mass and insulin content, and improves glycaemic control in an in vivo model (50 mg/kg; oral gavage; twice a day; for 15 days in double transgenic RIP-DTA male mice)

Catalog No. 50-003-38366