Medchemexpress LLC GNF4877 | 2041073-22-5 | 99.8% | 50 MG

Supplier:  Medchemexpress LLC HY12949250MG

GNF4877 is a potent inhibitor of DYRK1A and GSK3β, with IC50 values of 6 nM and 16 nM, respectively. This inhibitory action blocks the nuclear export of nuclear factor of activated T-cells (NFATc) and increases β-cell proliferation, making it suitable for research into metabolic and neurological diseases.

• Potent inhibitor of DYRK1A (IC50 6 nM) and GSK3β (IC50 16 nM)
• Blocks nuclear export of nuclear factor of activated T-cells (NFATc)
• Increases β-cell proliferation (EC50 0.66 μM for mouse β (R7T1) cells)
• Induces β-cell proliferation, increases β-cell mass and insulin content, and improves glycemic control in vivo
• Purity of 99.82%
• Molecular weight of 494.52
• Chemical formula C25H27FN6O4
• Appears as a light yellow to yellow solid
• Soluble in DMSO at 3.33 mg/mL

Catalog No. 50-003-41374