Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Golvatinib | 928037-13-2 | 99.9% | 25 MG
Supplier: Medchemexpress LLC 25MGHY13068
Golvatinib (E-7050) is a potent dual inhibitor of both c-Met and VEGFR2 kinases with IC50s of 14 and 16 nM, respectively. It effectively inhibits phosphorylation of c-Met and VEGFR-2, repressing the growth of c-Met amplified tumor cells and endothelial cells.
- Inhibits phosphorylation of c-Met and VEGFR-2
- Represses growth of c-Met amplified tumor cells and endothelial cells
- Circumvents resistance to EGFR-TKIs by blocking the Met/Gab1/PI3K/Akt pathway
- Prevents emergence of gefitinib-resistant cells
- Shows inhibition of c-Met and VEGFR-2 phosphorylation in tumors
- Strongly inhibits tumor growth and angiogenesis in xenograft models
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?