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Medchemexpress LLC Gossypol (acetic acid) | 12542-36-8 | 99.75% | 578.61 | 1 G
Supplier: Medchemexpress LLC HY175101G
Gossypol (acetic acid), also known as (±)-Gossypol-acetic acid, is a natural product isolated from cottonseeds and roots. It is an anticancer agent that has been studied and tested in several clinical trials. The racemic form is well tolerated and binds to Bcl-xL protein and Bcl-2 protein.
- Anticancer agent
- Natural product isolated from cottonseeds and roots
- Binds to Bcl-xL protein with a Ki of 0.5-0.6 μM
- Binds to Bcl-2 protein with a Ki of 0.2-0.3 mM
- Racemic form tested in clinical trials and well tolerated
- (-)-Gossypol enantiomer shows greater growth inhibition in certain cell lines
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