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Apexbio Technology LLC Granzyme B Inhibitor Z-AAD-CH2Cl 20ul (10 mM)
Supplier: Apexbio Technology LLC B59660.02
Granzyme B Inhibitor Z-AAD-CH2Cl is a small-molecule inhibitor targeting granzyme B a serine protease predominantly expressed in cytotoxic lymphocytes natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) It is designed to irreversibly inhibit granzyme B activity thereby modulating apoptosis induction and immune regulation Granzyme B Inhibitor Z-AAD-CH2Cl exerts its biological activity primarily through irreversible inhibition of granzyme B In cell-based studies it demonstrates inhibitory activity in models such as NK cell-induced cytotoxicity in chondrocytes lymphocyte-induced caspase-3 activation and DNA fragmentation and activation-induced apoptosis in T-cell populations Based on these pharmacological properties Granzyme B Inhibitor Z-AAD-CH2Cl holds research potential in immunology oncology and inflammation-related disorders
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