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Apexbio Technology LLC GS-7340 379270-37-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B80215.1
GS-7340 (379270-37-8) is a small-molecule inhibitor targeting HIV reverse transcriptase It is designed to inhibit this enzyme thereby interfering with viral genome replication by causing chain termination during DNA synthesis GS-7340 exerts its biological activity primarily as a phosphonamidate prodrug of tenofovir undergoing intracellular hydrolysis to produce active tenofovir diphosphate In in vitro studies GS-7340 demonstrates inhibitory activity against HIV replication with reported IC50 values ranging between 5 and 11 nM Based on these pharmacological properties GS-7340 holds research potential in antiretroviral studies and evaluations of drug metabolism pharmacokinetics and efficacy in lymphoid environments
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