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Medchemexpress LLC GSK-3β inhibitor 3 | 1448990-73-5 | 99.2% | C18H14FNO2S | 100 MG
Supplier: Medchemexpress LLC HY141480100MG
GSK-3β inhibitor 3 is a potent, selective, irreversible, and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) with an IC50 of 6.6 μM. This compound is suitable for research related to acute promyelocytic leukemia.
- Potent, selective, irreversible, and covalent inhibitor of GSK-3β
- Inhibits GSK-3α activity by 87.3%
- Dose-dependently inhibits the growth of NB4 and NB4-R1 cells
- Significantly increases the percentage of apoptosis in NB4 and NB4-R1 cells
- Minimal cytotoxicity on human normal liver cells and human umbilical vein endothelial cells
- Inhibits tumor growth in mice by 75.97%
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