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Apexbio Technology LLC GSK-3 Inhibitor IX (BIO) 667463-62-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B15385.1
GSK-3 Inhibitor IX (BIO CAS 667463-62-9) is a selective ATP-competitive reversible inhibitor targeting glycogen synthase kinase-3 (GSK-3) and isoforms showing potent inhibitory activity (IC50 for GSK-3 5 nM) GSK-3 a serine/threonine kinase modulates diverse cellular processes including insulin signaling neuronal health and cardiac function through Wnt/ -catenin pathways BIO promotes proliferation in mammalian cardiomyocytes by inducing cell cycle progression and -catenin signaling Additionally BIO sustains pluripotency in embryonic stem cells by activating canonical Wnt pathways and directly interacts with Wnt signaling components independent of AhR pathways
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