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Medchemexpress LLC GSK-J4 | 1373423-53-0 | 99.45% | 417.50 | 50 MG
Supplier: Medchemexpress LLC 50MGHY15648B
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50s of 8.6 μM and 6.6 μM respectively. This cell-permeable proagent of GSK-J1 induces endoplasmic reticulum stress-related apoptosis and inhibits LPS-induced TNF-α production in human primary macrophages.
- Potent dual inhibitor of H3K27me3/me2-demethylases
- Inhibits LPS-induced TNF-α production in human primary macrophages
- Cell-permeable proagent
- Induces endoplasmic reticulum stress-related apoptosis
- Increases total nuclear H3K27me3 levels in untransfected cells
- Reduces Jagged-1 mRNA and protein levels
- Promotes differentiation of Treg cells
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