Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000364267

Medchemexpress LLC GSK-J4 | 1373423-53-0 | 99.45% | 417.50 | 50 MG
SDP

Catalog No. 5000364267
Encompass_Preferred

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50s of 8.6 μM and 6.6 μM respectively. This cell-permeable proagent of GSK-J1 induces endoplasmic reticulum stress-related apoptosis and inhibits LPS-induced TNF-α production in human primary macrophages.

  • Potent dual inhibitor of H3K27me3/me2-demethylases
  • Inhibits LPS-induced TNF-α production in human primary macrophages
  • Cell-permeable proagent
  • Induces endoplasmic reticulum stress-related apoptosis
  • Increases total nuclear H3K27me3 levels in untransfected cells
  • Reduces Jagged-1 mRNA and protein levels
  • Promotes differentiation of Treg cells

Catalog No. 50-003-64267 Supplier Medchemexpress LLC Supplier No. 50MGHY15648B
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50s of 8.6 μM and 6.6 μM respectively. This cell-permeable proagent of GSK-J1 induces endoplasmic reticulum stress-related apoptosis and inhibits LPS-induced TNF-α production in human primary macrophages.

  • Potent dual inhibitor of H3K27me3/me2-demethylases
  • Inhibits LPS-induced TNF-α production in human primary macrophages
  • Cell-permeable proagent
  • Induces endoplasmic reticulum stress-related apoptosis
  • Increases total nuclear H3K27me3 levels in untransfected cells
  • Reduces Jagged-1 mRNA and protein levels
  • Promotes differentiation of Treg cells

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.