Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000401270

Medchemexpress LLC GSK1016790A | 942206-85-1 | 99.9% | 655.61 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY196085MG

Encompass_Preferred

GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. It can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells.

  • Elicits Ca2+ influx in mouse and human TRPV4-expressing human embryonic kidney (HEK) cells (EC50 values of 18 and 2.1 nM, respectively).
  • Evokes a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM.
  • Treatment elicits a rapid elevation of intracellular Ca2+ in a subset of neurons.
  • Produces a dose-dependent inhibitory effect on whole gut transit time in mice.
  • Significantly inhibits electrical field stimulation (EFS)-induced twitch contractions in isolated mouse colon strips in a concentration-dependent manner.

Catalog No. 50-004-01270


May include imposed supplier surcharges.
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.