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Apexbio Technology LLC GSK1070916 942918-07-2 5mg
SDP

Supplier:  Apexbio Technology LLC A41275

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GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways

Catalog No. 50-000-61542


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