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Medchemexpress LLC Gsk137647a | 349085-82-1 | 99.8% | 305.39 | 25 MG
Supplier: Medchemexpress LLC 25MGHY19995
GSK137647A is a potent and selective free fatty acid receptor 4 (FFA4) agonist. It exhibits high selectivity for human, mouse, and rat FFA4 with pEC50 values of 6.3, 6.2, and 6.1, respectively, and significantly lower activity on FFA1, FFA2, and FFA3. This compound demonstrates anti-inflammatory activity, promotes insulin secretion, and inhibits epithelial ion transport, linking it to the regulation of glucose homeostasis and anti-inflammatory responses.
- Reduces the production of nitric oxide in macrophages without affecting cell viability.
- Alleviates the response to inflammatory stimuli in Caco-2 cells and induces the secretion of IL-6.
- Reduces ion flow and affects colonic epithelial ion transport in healthy cells.
- Increases glucose-stimulated insulin secretion.
- Alleviates colitis in treated mice.
- Restores intestinal permeability in studies.
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