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Medchemexpress LLC GSK180736A | 817194-38-0 | 98.8% | 365.36 | 50 MG
Supplier: Medchemexpress LLC HY1899050MG
GSK180736A is a potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. It is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM. Structurally similar to paroxetine, it shows more potency and selectivity for GRK2 than other GRKs. ROCK1 is a potential therapeutic target in cardiovascular diseases like hypertension, and GSK180736A is a weak inhibitor of PKA with an IC50 of 30 μM.
- Potent rho-associated coiled-coil kinase 1 (ROCK1) inhibitor (IC50 = 100 nM)
- Selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor (IC50 = 0.77 μM)
- Structurally similar to paroxetine
- More than 100-fold selectivity over other GRKs
- Potential therapeutic agent for cardiovascular diseases such as hypertension
- Weak PKA inhibitor (IC50 = 30 μM)
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