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Apexbio Technology LLC GSK2292767 1254036-66-2 5mg
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Supplier:  Apexbio Technology LLC B61735

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GSK2292767 (CAS 1254036-66-2) is a potent and selective inhibitor of phosphoinositide 3-kinase delta (PI3K ) a lipid kinase involved in the regulation of cell growth proliferation differentiation and survival With a pKi of 10 1 GSK2292767 demonstrates over 100-fold selectivity for PI3K relative to other kinases in profiling assays In vitro studies show that it concentration-dependently inhibits IFN and IL-2 production in human lung parenchyma with pIC50 values of 8 7 and 8 5 respectively In vivo GSK2292767 reduces eosinophil recruitment in an acute OVA rat model (ED50 35 g/kg) and exhibits a favorable cardiovascular safety profile This compound is suitable for research on PI3K -mediated inflammatory respiratory diseases

Catalog No. 50-000-88334


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