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Medchemexpress LLC GSK256066 Trifluoroacetate | 1415560-64-3 | 99.8% | C29H27F3N4O7S | 1 ML
Supplier: Medchemexpress LLC HY7006910MM/1ML
GSK256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 3.2 pM for PDE4B. It is developed for the research of chronic obstructive pulmonary disease.
- Selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor
- IC50 of 3.2 pM for PDE4B
- Designed for inhaled administration
- Highly selective for PDE4
- Inhibits PDE4 isoforms A-D with equal affinity
- Inhibits tumor necrosis factor alpha production by lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes
- Inhibits eosinophil number in bronchoalveolar lavage in animal models
- Inhibits LPS-induced pulmonary neutrophilia
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