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Selleck Chemical LLC GSK2606414
Supplier: Selleck Chemical LLC S730710MM/1ML
GSK2606414 is an orally available potent and selective PERK inhibitor with IC50 of 0 4 nM displaying at least 100-fold selectivity over the other EIF2AKs assayed GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells
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