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Medchemexpress LLC Gsk2656157 | 1337532-29-2 | 416.45 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1382050MG

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GSK2656157 is a selective and ATP-competitive inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) with an IC50 of 0.9 nM. It inhibits PERK activation and decreases downstream substrates such as phospho-eIF2α, ATF4, and CHOP.

  • Blocks de novo protein synthesis after UPR induction
  • Inhibits the growth of HT1080 cells
  • Reduces LPS-induced IL-1β production, Caspase 1 activation, and eIF-2α phosphorylation
  • Demonstrates dose-dependent inhibition of phospho-PERK Thr980 in vivo
  • Inhibits tumor growth in human tumor xenograft models in vivo

Catalog No. 50-003-51279


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