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Apexbio Technology LLC GSK2656157 1337532-29-2 50mg
SDP

Supplier:  Apexbio Technology LLC B217550

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GSK2656157 (CAS 1337532-29-2) is a highly selective inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK) demonstrating an IC50 of 0 9 nM In kinase selectivity assays involving 300 kinases GSK2656157 displays marked specificity for PERK In cellular studies using BxPC3 pancreatic cancer cells this compound blocks PERK signaling reducing phosphorylation of downstream targets including eIF2 ATF4 and CHOP and subsequently suppressing protein synthesis In animal models bearing human tumor xenografts including pancreatic (BxPC3 HPAC Capan2) and multiple myeloma (NCI-H929) oral administration of GSK2656157 results in dose-dependent inhibition of tumor growth with notable sensitivity in Capan2 tumors

Catalog No. 50-000-62069


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