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Medchemexpress LLC Gsk3186899 | 1972617-87-0 | 99.0% | 491.53 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112622
GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12) that shows potent activity against L. donovani in intra-macrophage and cidal axenic amastigote assays. It demonstrates good selectivity against mammalian THP-1 host cells and comparable efficacy to miltefosine in a mouse model of infection, significantly reducing parasite levels. Non-clinical safety data supports its progression into regulatory preclinical studies.
- Inhibitor of cdc-2-related kinase 12 (CRK12)
- Potent activity against L. donovani
- Good selectivity against mammalian THP-1 host cells
- Comparable efficacy to miltefosine in reducing parasite levels
- Suitable therapeutic window for preclinical studies
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