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Cayman Chemical GSK3368715hydrochlorIde 10mg
Supplier: Cayman Chemical 3488610 MG
An inhibitor of type I PRMTs (IC50s = 3.1, 162, 38, 4.7, and 39 nM for PRMT1, 3, 4, 6, and 8, respectively); selective for type I PRMTs over PRMT5, 7, and 9 (IC50s = >20,408, >40,000, and >15,000 nM, respectively), as well as 20 additional methyltransferases and a panel of ion channels, receptors, and transporters at 10 µM; inhibits the growth of patient-derived DLBCL cells at 5 µM; reduces tumor volume in Toledo and BxPC-3 mouse xenograft models from 9.375-150 mg/kg; reduces tumor growth in ACHN and MDA-MB-468 mouse xenograft models and a pancreatic adenocarcinoma PDX mouse model at 150 and 300 mg/kg, respectively
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