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Medchemexpress LLC GSK461364 | 929095-18-1 | C27H28F3N5O2S | 200 MG
Supplier: Medchemexpress LLC HY50877200MG
GSK461364 is a potent, selective, reversible, and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with a Kᵢ value of 2.2 nM. It exhibits high selectivity for Plk1 over other kinases and can inhibit the growth of many proliferating cancer cell lines by inducing mitotic delay and apoptosis.
- Potent, selective, and reversible ATP-competitive Plk1 inhibitor
- Exhibits high selectivity for Plk1 over Plk2, Plk3, and other kinases
- Induces prolonged mitotic delay and aberrant mitotic exit
- Activates p53 in A549 and PL45 cells
- Inhibits proliferation of most cancer cell lines
- Blocks cells in G2-M phase and G2 and M phases of the cell cycle
- Causes M-phase caspase-3/caspase-7 activation
- Decreases PLK1 and pCDC25C levels
- Increases pHisH3, indicating mitotic arrest
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