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Medchemexpress LLC GSK805 | 1426802-50-7 | 98.0% | 1 ML
Supplier: Medchemexpress LLC HY1277610MM/1ML
GSK805 is an orally active and CNS penetrant RORγt inhibitor. It inhibits RORγ and Th17 cell differentiation, making it suitable for immunity research by inhibiting the function of Th17 cells.
- Orally active and CNS penetrant RORγt inhibitor
- Inhibits RORγt and Th17 cell differentiation
- Used for immunity research
- Demonstrates antiproliferative activity against CWR22R, LNCaP, and LNCaP C4-2B cells
- Inhibits IL-17 production during Th17 cell differentiation
- Improves EAE in mice
- Reduces IFN-γ-IL-17+ and IFN-γ+IL-17+ T cells in EAE mice
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