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Medchemexpress LLC Guadecitabine sodium | 929904-85-8 | C18H23N9NaO10P | 100 MG
Supplier: Medchemexpress LLC HY15229100MG
Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor. It is used in research for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
- Inhibits DNA methylation at the 5′-region
- Induces p16 gene expression
- Reduces DNA methylation in vivo
- Retards tumor growth in vivo
- Reactivates p16 gene expression in vivo
- Better tolerated than 5-Aza-CdR in vivo
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