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Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 500 G
Supplier: Medchemexpress LLC HYB0178A500G
Guanidine hydrochloride (Guanidinium chloride) is a strong chaotrope and a potent denaturant of proteins, intended strictly for research purposes.
- Facilitates the refolding of acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Induces co-operative unfolding of the molten globule state at concentrations exceeding 1 M.
- Does not interfere with disulfide bonds, preserving ordered protein structure.
- Effective in causing the loss of the stable [PSI+] element from yeast cells at millimolar concentrations.
- A 5 mM concentration in growth media cures [PSI+] and other yeast prions.
- Markedly diminishes Hsp104-mediated basal and acquired thermotolerance.
- Impairs Hsp104's capacity to restore activity in thermally denatured luciferase.
- Significantly lowered the death rate of infant mice infected with coxsackievirus A16 in studies.
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