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Medchemexpress LLC Guanoxabenz hydrochloride | 23256-40-8 | 283.54 | 10 MG
Supplier: Medchemexpress LLC HYU00123A10MG
Guanoxabenz hydrochloride is an α2 adrenergic receptor agonist, with a Kᵢ of 4000 nM and a fully activated form having a 40 nM affinity for an α2A adrenoceptor. It functions as a centrally active antihypertensive drug, demonstrated to reduce locomotor activity and influence EEG in animal models. Its high-affinity binding is influenced by N-hydroxyguanidine analogs and metabolic inhibitors.
- Functions as an α2 adrenergic receptor agonist.
- Acts as a centrally active antihypertensive drug.
- High-affinity binding inhibited by N-hydroxyguanidine analogs.
- Spleen cytosolic fraction converts Guanoxabenz to guanabenz.
- Reduces locomotor activity in rats dose-dependently.
- Influences EEG and behavioral effects.
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