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Medchemexpress LLC Guanoxabenz hydrochloride | 23256-40-8 | 283.54 | 25 MG
Supplier: Medchemexpress LLC 25MGHYU00123A
Guanoxabenz hydrochloride, also known as Hydroxyguanabenz hydrochloride, is an α2 adrenergic receptor agonist. It acts as a centrally active antihypertensive drug and is intended for research use only.
- Acts as an α2 adrenergic receptor agonist.
- Displays a Ki of 4000 nM for an α2A adrenoceptor, with 40 nM for its fully activated form.
- Recognized as a centrally active antihypertensive drug.
- High-affinity binding can be inhibited by N-hydroxyguanidine analogs and various metabolic inhibitors.
- Reduction to guanabenz, with higher affinity for alpha2A-adrenoceptors, is mediated by spleen cytosolic fraction.
- Induces high-affinity binding in rat brain membranes with NADH or NADPH cofactors.
- Causes a dose-related reduction in locomotor activity in vivo.
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