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Medchemexpress LLC Guanoxabenz hydrochloride | 23256-40-8 | 283.54 | 5 MG
Supplier: Medchemexpress LLC HYU00123A5MG
Guanoxabenz hydrochloride is an α2 adrenergic receptor agonist intended for research use only. It presents as an off-white to gray solid and is soluble in DMSO at 83.33 mg/mL. It exhibits a Ki of 4000 nM, with its fully activated form having a Ki of 40 nM for an α2A adrenoceptor.
- Inhibits high-affinity binding by N-hydroxyguanidine analogs and metabolic inhibitors.
- Reduction to guanabenz mediated by spleen cytosolic fraction, increasing alpha2A-adrenoceptor affinity.
- Acts as a centrally active antihypertensive drug.
- Induces high-affinity binding in rat brain membranes with NADH or NADPH cofactors.
- Rat cerebral cortex contains enzymatic activity for compound activation.
- Causes dose-related reduction in locomotor activity in vivo.
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