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Apexbio Technology LLC GW4064 278779-30-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B15275.1
GW4064 (CAS 278779-30-9) is a non-steroidal agonist targeting the farnesoid X receptor (FXR) a nuclear receptor involved in lipid and cholesterol regulation Reported EC50 values of GW4064 for FXR activation are approximately 15 nM in isolated receptor assays and 90 nM in human FXR-transfected cell studies In animal models including KK-Ay and ob/ob mice GW4064 administration was associated with reduced serum triglyceride (TG) concentrations and diminished very-low-density lipoprotein (VLDL) production However due to limitations such as poor solubility chemical instability under UV exposure and a potentially toxic stilbene pharmacophore GW4064 primarily serves as a research tool for investigating FXR signaling pathways
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