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AdipoGen GW501516,Chemical. 317318-70-0;
Supplier: AdipoGen AGCR13641M025
GW501516, AdipoGen Life Sciences. Chemical. 317318-70-0. Formula: C21H18F3NO3S2. MW: 453.5. Potent & selective peroxisome proliferator-activated receptor (PPAR) delta agonist/activator with high affinity (Ki=1nM) & potency (EC50=1nM) for PPARdelta & >1000 fold selectivity over PPARalpha & PPARgamma. The peroxisome proliferator-activated receptor delta (PPAR delta) has emerged as an important regulator of lipid homeostasis & inflammatory signaling. Recent in vitro, in vivo & human clinical studies have highlighted a role for PPARdelta activation in the prevention & treatment of insulin resistance & atherosclerosis. Antidiabetic compound. Shown to activate pathways initiated through exercise & was investigated as a potential treatment for obesity, diabetes, dyslipidemia & cardiovascular disease. Off-target high doses lead to tumor progression in rodents. Increases ABC A1 transporter expression & induces apolipoprotein A1-mediated cholesterol efflux in vitro. 317318-70-0
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