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Enzo Life Sciences GW5074 (25mg). CAS: 220904-83-6
Supplier: Enzo Life Sciences BMLEI3070025
Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism. Alternative name: 5-Iodo-3- (3 5-dibromo-4-hydroxyphenyl)methylene -2-indolinone. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25 mg/ml). Long Term Storage: -20°C.
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