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Medchemexpress LLC GW806742X hydrochloride | 98.3% | 610.01 | 10 MG
Supplier: Medchemexpress LLC HY112292A10MG
GW806742X hydrochloride is an ATP mimetic and a potent inhibitor of MLKL (Mixed Lineage Kinase Domain-Like protein), binding to its pseudokinase domain with a Kd of 9.3 μM. It also shows activity against VEGFR2 with an IC50 of 2 nM. This compound effectively retards MLKL membrane translocation and inhibits necroptosis.
- Potent MLKL inhibitor (Kd = 9.3 μM)
- Activity against VEGFR2 (IC50 = 2 nM)
- Retards MLKL membrane translocation
- Inhibits necroptosis
- Inhibits necroptotic death of wild-type mouse dermal fibroblasts in a dose-dependent manner
- Inhibits VEGF induced proliferation of HUVECs with an IC50 of 5 nM
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