Medchemexpress LLC H-151 | 941987-60-6 | 99.86% | 279.34 | 1 ML

Supplier:  Medchemexpress LLC HY11269310MM/1ML

H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. It can be used for the research of autoinflammatory disease.

• Potent, selective, and covalent antagonist of STING.
• Exhibits noteworthy inhibitory activity in cells and in vivo.
• Reduces TBK1 phosphorylation.
• Suppresses STING palmitoylation.
• Useful for research of autoinflammatory disease.
• Reduces IFNβ luciferase reporter measurements.
• Inhibits phosphorylation of TBK1.
• Suppresses palmitoylation.
• Markedly reduces systemic cytokine responses.
• Exhibits notable efficacy in certain mouse models.
• Reaches effective systemic levels.
• Displays a short half-life in serum.
• Forms an adduct to mmSTING.

Catalog No. 50-004-37873