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Medchemexpress LLC HaloPROTAC-E | 2365478-58-4 | 98.76% | C39H56ClN5O8S | 1 MG
Supplier: Medchemexpress LLC HY1457521MG
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. It significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.
- Potent Halo PROTAC degrader
- Reversibly induces degradation of Halo-tagged SGK3 and VPS34
- DC50 of 3-10 nM
- Significantly and selectively degrades endogenous VPS34 complexes
- Inhibits autophagy
- Rapid and complete depletion of Halo-tagged SGK3 in vitro
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