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BioVendor, LLC Hyaluronan and proteoglycan link protein 1 (HAPLN1) Human, E.coli Recombinant Protein (1 mg)
Supplier: BioVendor, LLC RP17220121MG
Hyaluronan and proteoglycan link protein 1 (HAPLN1) Human, E.coli Recombinant Protein (1 mg): a single, non-glycosylated polypeptide chain, 362 amino acids (16-354 a.a.), MW of 40.9kDa. HAPLN1 is fused to 23a.a. His-tag at N-terminus. Sterile filtered solution (1mg/ml) with 20mM Tris-HCl buffer (pH8), 0.4M Urea and 10% glycerol. SUMMARY: In cartilage ECM, HAPLN1 stabilizes the aggregates of proteoglycan monomers by means of HA. In the absence of HAPLN1, aggregates are smaller and less stable. HAPLN1 binds aggrecan along the HA chain and the resulting aggregates are entrapped within the mesh-like network of type II collagen fibrils producing a stable macromolecular structure that contributes to compression resistance/shock absorption in the joint. HAPLN1 is also highly expressed in noncartilaginous tissues (ex. small intestine, placenta, heart) and to a lower extent, many other tissues. OTHER NAMES: Cartilage-linking protein 1, Cartilage-link protein, Proteoglycan link protein, CRTL1
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