Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC HC 067047,10mg CAS# 883031-03-6
Supplier: Apexbio Technology LLC B758810
HC067047 is a selective TRPV4 antagonist with IC50 of 48 nM, 133 nM and 17 nM for human, rat and mouse TRPV4, respectively[1]. In HEI-OC1 cells, HC067047 (1 µM) treatment for 24 hours can significantly reduce the mRNA expression in HEI-OC1 cells cultured in high glucose and reduce the expression of TRPV4 protein. HC067047 (1 µM) treatment for 48 hours can inhibit cell proliferation and promote apoptosis[2]. In WT mice with cystiti, HC067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes) treatment increases functional bladder capacity and reduces micturition frequency. HC067047 do not affect bladder function in Trpv4−/− mice[1]. Other sizes are also available. Please inqury us for quote.
This item is not returnable.
View return policy
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction