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Medchemexpress LLC HC-070 | 1628291-95-1 | 99.74% | 475.32 | 10 MG
Supplier: Medchemexpress LLC HY11230210MG
HC-070 is a potent and selective antagonist of TRPC4 and TRPC5 channels, demonstrating IC50s of 9.3 nM for hTRPC5 and 46 nM for hTRPC4. It exhibits high selectivity, with at least 400-fold preference for human TRPC4 and TRPC5-containing channels over other examined channels. This compound also modulates TRPC1/TRPC4 and TRPC1/5 channels and reduces neuronal activity in amygdala slices.
- Inhibits TRPC4/TRPC5 channels.
- Shows high selectivity for TRPC4 and TRPC5-containing channels.
- Modulates TRPC1/TRPC4 and TRPC1/5 channels.
- Reduces neuronal activity in amygdala slices.
- Weakly inhibits TRPC3.
- Inhibits lanthanum-activated TRPC5-mediated currents.
- Blocks M2R-activated TRPC1/TRPC4 channels.
- Inhibits human TRPC5 currents activated via muscarinic type 1 (M1R).
- Suppresses hTRPC4 currents via M2R.
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