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Enzo Life Sciences HELSS (25 mg). CAS: 88070-98-8
Supplier: Enzo Life Sciences BMLST3400025
HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM). Alternative name: Haloenol lactone suicide substrate. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml). Long Term Storage: -20°C.
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