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Apexbio Technology LLC HG-9-91-01 1456858-58-4 100mg
Supplier: Apexbio Technology LLC B1052100
HG-9-91-01 (CAS 1456858-58-4) is a small-molecule inhibitor of salt-inducible kinases (SIK) selectively targeting SIK1 SIK2 and SIK3 with IC50 values of 0 92 nM 6 6 nM and 9 6 nM respectively SIK inhibition results in enhanced CREB-dependent gene transcription and elevated IL-10 production in response to LPS stimulation while decreasing pro-inflammatory cytokine secretion and promoting regulatory macrophage differentiation HG-9-91-01 also displays inhibitory activity against several protein tyrosine kinases including Src BTK FGF receptors and Ephrin receptors but does not notably affect other AMPK-related kinase subfamily members This compound is used in research addressing inflammatory and autoimmune disorders
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