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ABclonal Technology HIF1/ARNT Rabbit mAb
Supplier: ABclonal Technology A19532100UL
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus where it promotes the expression of genes involved in xenobiotic metabolism This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1 Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias Alternative splicing results in multiple transcript variants
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